Recovering scientist turned early stage VC A biotech optimist fighting gravity

Want Better Odds? Get a Pharma Corporate VC to Invest
May 22, 2012

Pharma corporate venture was back in the biotech news today with the release of Burrill & Company’s June 2012 report.  An interesting article by Vinay Singh evaluated the impact of Pharma corporate venture capital (CVC) investing, and the key takeaway

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Not-so-Breaking News: The VC Model Needs Retooling
May 15, 2012

“We Have Met the Enemy… And He is Us” is the very fitting title of a recent report on the state of the VC market with a focus on the GP-LP relationship.  This thoughtful and thankfully analytical report highlights a

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Biotech Past, Biotech Present: Reflections on the IPO Window of 1991-1994
May 2, 2012

Twenty years ago the biotech world was in the midst of one of the best IPO windows in its history.  Nearly a hundred biotech companies went public from 1991-1994, including a number of the great companies that have become household

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Culture as a Culprit of the Pharma R&D Crisis
April 19, 2012

Everyone knows about the Pharma industry’s R&D productivity woes, but few seem to have solutions that work. Part of treating the problem requires an accurate diagnosis, and this winter’s work in Nature Reviews Drug Discovery by Scannell et al from

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Biotech VC Returns: Diversified Funds vs. Healthcare-only Funds
April 9, 2012

Over the past decade biotech investments made by diversified venture capital firms have outperformed those by healthcare-focused firms.  Its unclear why the difference exists, but the historical data suggest it’s a striking differential. Examining the NVCA Benchmarking Database powered by

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Virtues of Differing Biotech Worldviews
March 27, 2012

Debating the merits of various biotech business models is in vogue today, in part as a response to the proliferation of experiments around the right form and function of the companies themselves.  An often asked question: are we supporting CEOs

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The Biotech Venture Capital Math Problem
March 15, 2012

Everyone has heard of the monster returns to some venture funds from high-flyng social media and technology companies: Facebook’s potential 800x for Accel, Google’s 350x for KPCB and Sequoia, Zynga’s 100x+ for Union Square, Foundry, and Avalon.  These single big

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High-Performing Boards in Early Stage Biotech
March 3, 2012

Having a highly functional and productive Board of Directors is a key ingredient for success for most companies, but its of particular importance for early stage startups. The web is full of advice around what are the “best practices” for venture-backed

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Paying Attention to Biotech M&A Earnout Payments
February 22, 2012

In recent years, acquisitions of early stage private biotechs have frequently included an upfront value coupled with significant future milestone payments. These earnouts resemble the “biobucks” common to product licensing deals: stretching out over 5-10 years, they get ravaged by

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Return of the Jedi: Stromedix Acquired by Biogen
February 14, 2012

Biogen just announced its acquisition of Stromedix for up to $562M. Another solid M&A exit in biotech emphasizing how innovation matters. With a very different model than Avila Therapeutics, an exit we announced in January, Stromedix is a biology-focused, asset-centric

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Bridging The Real Gap in Biotech Venture Funding: the Elusive Series B
February 9, 2012

Biotech pundits often talk about the challenge of raising an initial round of capital for drug discovery startups, highlighting the perceived “gap” in early stage funding.   And it certainly isn’t easy raising that first significant round of institutional capital.  But

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Avila Therapeutics Strikes A Covalent Corporate Bond With Celgene
January 26, 2012

Today Celgene announced the acquisition of Avila Therapeutics for $350M upfront and up to $575M in future milestones.  Congratulations to the Avila team!  For those of us involved in the story, we certainly think Celgene’s got itself a great deal.

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