Recovering scientist turned early stage VC A biotech optimist fighting gravity

Twenty Years In Early Stage Biotech VC (Part 3): Business
October 16, 2025

At the end of the day, biotech venture capital is a business and driving returns is the ultimate metric. For twenty years, to deliver on that, I’ve embraced what I call the “first principle” of early stage biotech investing: if

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Twenty Years In Early Stage Biotech VC (Part 2): People
October 15, 2025

Talented people make the magic happen in biotech.  This is the second post in my “Twenty Years In Early Stage Venture” trifecta. Yesterday’s was on Science. Today we’re talking about the People part of biotech. After a couple decades and

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Twenty Years In Early Stage Biotech VC (Part 1): Science
October 14, 2025

In the blink of an eye, twenty years have passed: in mid-October 2005, I joined Atlas Venture as a principal on the global life science team.  We closed Fund VII a few months after I joined; and, just a few

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Speed Wins: The Focused-Team Formula for Platform Biotechs
September 9, 2025

By Ram Aiyar, CEO of Korro Bio, as part of the From The Trenches feature of LifeSciVC Let me tell you a secret that most biotech executives won’t admit at cocktail parties: we’re all making it up as we go

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A Delicate Balance: Building NewCos with Jacks of All Trades and Utility Players
August 27, 2025

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC Building the right team is a popular topic because it is difficult and a company’s success hinges on it. In a cash-crunched biotech

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The Intelligent Entrepreneur: Real and Illusory Margins of Safety in Company Building 
August 19, 2025

By Ankit Mahadevia, founder and board director of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC Biotech leaders love talking about ‘margin of safety’—but what if the safety nets we build are just illusions? In The Intelligent

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A [Prime]r on Stock Option Repricing in Biotech
August 14, 2025

By Cody Tranbarger, EIR at Atlas Venture, as part of the From The Trenches feature of LifeSciVC As the biotech industry trudges through its fourth consecutive year of middling performance and sluggish capital markets, corporate governance has become a salient

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A “Complex” Solution to a “Complex” Problem? Attacking KRASG12X Colorectal Cancer Through the CBM Signalosome
July 31, 2025

By Gerry Harriman, CSO and co-founder of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC As scientists, we are accustomed to learning something new about targets (and the modulation thereof) that moves the field forward in

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Best Practices for Pitching, Geared Towards First-Time Founders
July 10, 2025

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC If you are a first-time founder who has heard the phrase “This isn’t a good time to be raising for X,” where X

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Leadership in the Age of Stacks
July 8, 2025

By Jason Campagna, CMO of Q32, as part of the From The Trenches feature of LifeSciVC In a recent essay, I argued that biotech is entering its strategic infrastructure moment, a shift from molecule-centric innovation to a layered capability stack

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Building Korro Bio: A CEO’s Perspective on Innovation and Risk Management
June 12, 2025

By Ram Aiyar, CEO of Korro Bio, as part of the From The Trenches feature of LifeSciVC It has been an extraordinary journey so far and one that continues to humble, inspire and motivate me every day. I’ve had the

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“We Got This”:  Don’t Let Negativity Become a Self-fulfilling Prophecy
June 5, 2025

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC It’s easy to jump on the ‘negative bandwagon’ these days when news in our world and industry is focused on doom & gloom.

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