Recovering scientist turned early stage VC A biotech optimist fighting gravity

The White House’s National Microbiome Initiative: My Reflections
June 2, 2016

This blog was written by JC Gutierrez-Ramos, CEO of Synlogic, as part of the From The Trenches feature of LifeSciVC.   Despite being central to life on earth, we know little about how microbes interact with each other, their hosts and

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Riding The Gene Editing Wave: Reflections On CRISPR/Cas9’s Impressive Trajectory
May 31, 2016

CRISPR/Cas genome editing has captured the attention of the popular media, scientific community, and the investment world: the promise of going into a cell and precisely making changes in their genetic code to cure them of illness is certainly captivating.


Our Experience With First-Time Biotech CEOs: Five Behaviors That Matter
May 25, 2016

Jumping into a first-time CEO role in an emerging biotech is a daunting but exciting opportunity – both for the newly-minted chief executive and their Board of Directors. A great hire can be positively catalytic to a startup; and, sadly,


Of Mice And Men: Translation In Psychiatric Disease
May 12, 2016

This blog was written by Vanessa King, CEO of Luc Therapeutics, as part of the From The Trenches feature of LifeSciVC Almost 15 years ago – in 2003, to be precise – I was working with genome sequencing pioneer Craig


A Tale of Two Startup Worlds: Biotech And Tech VC Ecosystems
May 9, 2016

Startup ecosystems supported by venture capital are defined by dynamism, with the creation, growth, exiting, or failure of new innovative companies conspiring to keep these entrepreneurial landscapes in constant change. Investor returns and sentiment are dramatically impacted by how these

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Riding Dancing Unicorns Down The Road To Recap
May 2, 2016

This post was written by Michael Gladstone, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC. Ex-Citigroup CEO Charles Prince famously said in July 2007, regarding Citi’s leveraged lending business, “As long as the music

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Moving From Academia To Successful Biotech: Optimizing Tech Transfer
April 26, 2016

University tech transfer offices play a central role in the biotech ecosystem, as the successful commercialization of an academic discovery is the aspiration of many young startups. Navigating – and optimizing – this tech transfer process is therefore critical to the

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Unpredictable Precedent: Bread, Circuses, And The Termination of Pfizer-Allergan
April 12, 2016

Last week, when the Treasury effectively scuttled the Pfizer-Allergan merger, there was much rejoicing: politicians and pundits alike were thrilled that tax inversion greed had been stopped, and that companies like Pfizer would have to “pay their fair share.”  Investors

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Raising Capital As A Private Biotech: Insights From Unum Therapeutics’ Series B Round
April 6, 2016

This blog was written by Christiana Stamoulis, CFO and Head of Corporate Development at Unum, as part of the “From The Trenches” feature of LifeSciVC. In June 2015 Unum Therapeutics closed a $65M a Series B round, bringing in capital

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Nimbus Delivers Its Apollo Mission: A $1.2B Gilead Partnership
April 4, 2016

Today Gilead announced the acquisition of Nimbus’ lead program targeting NASH and related metabolic disorders for $400M upfront and up to another $800M in development and regulatory milestones (here). This transformative deal is the culmination of over five years of work on

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BMS Secures The Keys To Padlock
March 23, 2016

Today we announced the acquisition of Padlock Therapeutics by BMS for up to $600M in total deal value (here), bringing a bittersweet end to a great startup story and the start of a promising and likely productive portfolio for BMS.

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Putting It In Reverse
March 18, 2016

This blog was written by Ron Renaud, CEO of RaNA Therapeutics, as part of the From The Trenches feature of LifeSciVC. Much of the discussion I have had had with my colleagues in publicly traded biotech companies over the last

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