Recovering scientist turned early stage VC A biotech optimist fighting gravity

Balancing the Risks and Rewards of Drug Development in China: A Small Biotech CEO Perspective
March 17, 2026

By Jonathan Montagu, CEO and co-founder of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC Of the recurring themes that tend to circulate in the drug development discourse,  China is a uniquely fascinating and polarizing subject.

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Ex-US Clinical Trials: Tribulations, Preparations, and Expectations
March 13, 2026

By Arthur Tzianabos, CEO of Lifordi Immunotherapeutics, as part of the From The Trenches feature of LifeSciVC As biotech companies tackle the escalating time and cost of clinical trials, the decision to conduct early-stage, proof-of-concept studies outside the U.S. is

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Dual Wielding in I&I: A Pivotal Year Ahead
February 17, 2026

By Cody Tranbarger, Entrepreneur In Residence at Atlas Venture, as part of the From The Trenches feature of LifeSciVC   What if the biggest obstacle to the next generation of I&I therapeutics isn’t finding better targets — but accepting that

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Why Owning the Learning Loop Matters More Than Owning the Lab
January 27, 2026

By Abbas Kazimi, CEO of Nimbus Therapeutics, as part of the From The Trenches feature of LifeSciVC In early 2009, when global markets were bottoming out, you can imagine what it felt like walking the halls of the JPM Healthcare

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Chaos is a Ladder: Predictions for 2026
January 7, 2026

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC. I’m not a resolutions person but I’ve always loved the start of the year – there is something about turning the page on

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Back to Late Stage: Where the Hard Problems Live
December 9, 2025

By Jason Campagna, biotech executive, as part of the From The Trenches feature of LifeSciVC I recently joined Inventiva Pharma, a late-stage company developing a therapeutic for metabolic disease and MASH, a field that is both scientifically complex and once

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CMC: A ‘Secret Sauce’ of Biotech Success
December 3, 2025

By, Arthur Tzianabos, CEO of Lifordi, as part of the From The Trenches feature of LifeSciVC I often hear biotech leaders refer to their company’s technology and approach in terms of the “secret sauce” or “how the sausage gets made.”

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Atlas Venture 2025 Year In Review
November 24, 2025

This year has truly been a rollercoaster!  The markets started off with optimism, but then collapsed into the spring, only to rebound with enthusiasm in recent months. The cadence of M&A has picked up, creating a tailwind for the sector. 

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Death, Grief, and the Drive to Build Better Therapies
November 18, 2025

By Abbas Kazimi, CEO of Nimbus Therapeutics, as part of the From The Trenches feature of LifeSciVC Hospitals were never meant to be familiar to me, yet for over twenty years MD Anderson became a place I could navigate by heart: the

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A CEO’s Perspective on Navigating Choppy Market Waters
November 13, 2025

By Jonathan Montagu, CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC I’m far from the first person to point out the prolonged market challenges that have depressed the biotech fundraising environment over the past

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Everything I Know I Learned In Graduate School
November 7, 2025

By Mike Gilman, serial entrepreneur and veteran biotech executive, as part of the From The Trenches feature of LifeSciVC My thesis advisor, Mike Chamberlin, passed away last week. I owe much of who I am as a scientist to him.

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Twenty Years In Early Stage Biotech VC (Part 3): Business
October 16, 2025

At the end of the day, biotech venture capital is a business and driving returns is the ultimate metric. For twenty years, to deliver on that, I’ve embraced what I call the “first principle” of early stage biotech investing: if

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