Recovering scientist turned early stage VC A biotech optimist fighting gravity

State of the Industry: 2021 Year In Review
November 16, 2021

We just held our first-ever, and hopefully only, virtual Atlas Venture Annual Meeting for our investors. Although science is winning in this pandemic, we’re clearly not back to normal yet so felt it prudent to shift to a virtual format.

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Understanding The Business Model Of Gene Therapy Companies – Peeling The Onion Back To Understand Why Time Matters
November 4, 2021

By Deanna Petersen and Holly May, Chief Business Officer and Chief Commercial Officer, respectively, of AVROBIO, as part of the From The Trenches feature of LifeSciVC Moving from traditional drug development and commercialization to gene therapy development and commercialization can

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Spreading The Word: Using Different Mediums To Get The Message Out To Your Team
November 1, 2021

By Ankit Mahadevia, CEO and founder of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC Recently, Spero announced the filing of its first ever New Drug Application, for our medicine tebipenem Hbr.  Interestingly, as we approached

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Empowering Therapeutic Advances With Early Patient Engagement
October 7, 2021

By Josh Brumm, CEO of Dyne Therapeutics, as part of the From The Trenches feature of LifeSciVC One morning in early June I was reading my LinkedIn feed and saw something that caught my eye – a university was establishing

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Model Behavior
September 29, 2021

By Aoife Brennan, CEO of Synlogic Therapeutics, as part of the From The Trenches feature of LifeSciVC The COVID-19 pandemic has upended life as we know it. Given so much uncertainty, it is a normal human impulse to want some

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In the Shadows
August 23, 2021

By Philip Astley-Sparke, CEO of Replimune, as part of the From The Trenches feature of LifeSciVC. I recently stepped down after a six-year stint as Chairman of uniQure (NASDAQ: QURE). In the process of interviewing potential successors, one candidate observed

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Mind Your Manners: Best Practices and Basic Etiquette in Business Development
August 16, 2021

By Deanna Petersen, CBO of AVROBIO, as part of the From The Trenches feature of LifeSciVC It’s tempting to think that the first skill you need to learn in business development is negotiating. That’s important, of course, but it should

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Scaling Thoughtfully: The Art Of Sharing Responsibilities Across A Growing Team
July 27, 2021

By Ankit Mahadevia, CEO and Founder of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC. The opportunity for each member of a NewCo to take on multiple responsibilities selects early for people ready to help a

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Immuno-Oncology: The Comeback Kid
July 13, 2021

By Tim Reilly & Jonathan Montagu, CDO and CEO of HotSpot Therapeutics, as part of the From The Trenches feature of LifeSciVC Now 10 years into the golden era of immuno-oncology (I-O) following the first FDA approval of ipilimumab (anti-CTLA4)

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SPAC downpour continues
July 9, 2021

By Sam Truex, Venture Partner at Atlas Venture, as part of the From The Trenches feature of LifeSciVC. Holy cow, have we seen the rain lately – both downpours outside and a downpour of SPAC activity. In October 2020, Bruce

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Playing To Win: Building A Position Of Strength In Biotech
July 8, 2021

By Joshua Brumm, CEO of Dyne Therapeutics, as part of the From The Trenches feature of LifeSciVC When I play board games, I play to win. That requires thinking several moves ahead. In the game Risk, for instance, it’s not

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Targeted Protein Degradation: The First Proof-of-Mechanism in a Randomized, Placebo-Controlled Study
July 6, 2021

By Nello Mainolfi, PhD, Co-Founder, President and CEO of Kymera Therapeutics, as part of the From The Trenches feature of LifeSciVC. The inherent ability to combine the power of genetic-like knockdown with the flexibility of small molecules; the power to

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