Recovering scientist turned early stage VC A biotech optimist fighting gravity

So, Your Board Asked For A Deal This Year?
January 30, 2018

This blog was written by Jeb Keiper, CFO & CBO of Nimbus Therapeutics LLC, as part of the From The Trenches feature of LifeSciVC. A fresh Q1 is underway, your meetings at JPMorgan were top notch, and you have a

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Two CARTs, Two Charts: Dissecting Returns From T-Cell Therapy M&A
January 23, 2018

Yesterday Celgene finalized its acquisition of Juno Therapeutics for $9B, only a few short months after Gilead bought Kite Pharma for $11.9B. With only a few hundred patients ever treated with their therapies, $20B represents a lot of promise in

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Reaping What We Sow: Seeds Planted Long Ago Prepare to Bear Fruit In 2018
January 17, 2018

This blog was written by Michael Gladstone, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC. Biotech newsflow came out the gate a little slow in 2018 (though it appears it may be speeding up

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Snow, Skiing, And My 2018 Outlook For Biotech
January 4, 2018

As 2018 begins, and we prepare for the biopharma sector’s annual kickoff in San Francisco next week, my thoughts are focused on the snow. I’m literally watching bombogenesis unleash a blizzard white-out in Boston right now. As a winter sports

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Report Card For 2017: My Crystal Ball Predictions For Biotech
December 22, 2017

Heading into the winter holidays always brings out festive reflections of the past year. Twelve months ago, we were thrilled to say goodbye to 2016 and excited to embrace 2017’s promise.  And in large part, the past year has delivered

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Portfolio Scorecard: Atlas’ Biotech Seed Class of 2013
December 13, 2017

Four years ago, in December 2013, I highlighted Atlas’ seed-led venture creation model by walking through our Fund IX Seed Class of 2013.  Only a short 1400 days ago, reading it again last week made it seem like an eternity.

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Operating Systems For Living Medicines
December 6, 2017

This blog was written by Mike Gilman, CEO of Obsidian Therapeutics and Atlas Advisor, as part of the From The Trenches feature of LifeSciVC. Consider the leech – the first living medicine. In its heyday in the 19th century –

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In Search Of Novelty: 2017’s New FDA Drug Approvals
November 30, 2017

It’s been an exciting year for new drug approvals, with the FDA on a similar pace to the gangbuster year of 2015. Many of these new medicines address significant and meaningful needs, or offer additional therapeutic choices for patients and

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Brexit – Own Goal Or Overhead Kick?
November 27, 2017

This blog was written by Ros Deegan, CBO of Bicycle Therapeutics, as part of the From The Trenches feature of LifeSciVC. On June 27, 2016 England’s soccer team was knocked out of the European Championships by Iceland – a tiny

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Painful Truth: Successful Failure Of A Biotech Startup
November 17, 2017

Back in the summer, I got the call that no biotech venture investor wants to get. On the morning of August 8th, I received an urgent text of “can you talk now?” quickly followed with a call. I learned then

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Living Medicines With Curative Intent: Small N’s Go Viral
November 7, 2017

The field of gene and cell therapy has witnessed an unprecedented few months, almost unimaginable only a few years ago. It’s worth pausing to reflect on some of the recent highlights: FDA approval of two chimeric antigen receptor (CAR) T-cell

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Drugging The Undruggable: Kymera’s Targeted Protein Degradation
October 30, 2017

The term “undruggable” has entered common industry vernacular over the past two decades to describe biologic targets that couldn’t be addressed via narrow conventional pharmacologies involving catalytic-site inhibitors and antibodies. The “druggable genome” historically included intracellular catalytic proteins, (e.g., enzymes

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